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Studies in vitro have demonstrated that tadalafil is a selective inhibitor of PDE5, PDE5 is found in corpus cavernosum smooth muscle, vascular and visceral smooth muscle, skeletal muscle, platelets, kidney, lung, cerebellum, and pancreas. The change reflects a small number of postmarketing reports of sudden vision loss attributed to NAION nonarteritic ischemic optic neuropathy small number of postmarketing reports of sudden vision loss attributed to NAION nonarteritic ischemic optic neuropathy, a condition in which blood flow is blocked to the optic nerve, states an FDA news release.
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