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Ortho-McNeil had previously asserted US Patent No 5,336,691 the predecessor patent to RE39,22 against Barr and Kali Labs PRX symptom buy tablet tramadol. Industry giants GlaxoSmithKline and Eli Lilly have ampakine programmes of their own, and at least one other company, Arena Pharmaceuticals of San Diego, California, has declared an interest in wakefulness promoters, though it hasnt released any details of its research.